Consider the following statements regarding Sickle Cell Anaemia:

i. It is caused due to genetic mutation.
ii. It affects the shape of red blood cells and reduces their ability to carry oxygen.
iii. It can be treated by bone marrow or stem cell transplantation.
iv. Sickle Cell Disease causes the body to make normal haemoglobin.

The incorrect statement(s) is/are

Question

Consider the following statements regarding Sickle Cell Anaemia:

i. It is caused due to genetic mutation.

ii. It affects the shape of red blood cells and reduces their ability to carry oxygen.

iii. It can be treated by bone marrow or stem cell transplantation.

iv. Sickle Cell Disease causes the body to make normal haemoglobin.

The incorrect statement(s) is/are

Quintessence Classes · Accepted Answer

The correct answer is iv only. Statement i is correct: It is a hereditary genetic disorder caused by a mutation in the HBB gene.Statement ii is correct: The mutation causes red blood cells to become rigid and "C-shaped" (like a sickle). These cells get stuck in small blood vessels and cannot carry oxygen efficiently.Statement iii is correct: While difficult and risky, bone marrow or stem cell transplants are currently the only known cures for the disease.Statement iv is INCORRECT: Sickle Cell Disease causes the body to produce abnormal hemoglobin (called Hemoglobin S), which causes the red blood cells to stiffen and malform. It specifically prevents the body from making only normal hemoglobin.

Answer

i only

Answer

iii only

Answer

ii and iii only

Answer & Explanation

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JKPSC JKAS 2024 Prelims

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